La sГntesis se llevГі a cabo en dos pasos. Las bencenosulfonamidas fueron obtenidas por la reacciГіn del grupoДў-amino del ciclo tiazГіlico a sulfonamida por medio de una reacciГіn de sulfonamidaciГіn, en la que el grupo amino reaccionГі contra un agente sulfonante en este caso, un cloruro de sulfonilarilo y un catalizador como el DMAP (N-dimetil amino piridina). Finally, X-ray diffraction analysis was executed for any crystalline structure obtained.Д®n el presente trabajo se realizГі la sГntesis, aislamiento e identificaciГіn espectroscГіpica de 21 bencenosulfonamidas derivadas de 2-amino-4-ariltiazoles. The 21 compounds were analyzed by resonance nuclear magnetic (NMR) spectroscopy and mass spectrometry (MS). The synthesized compounds were purified by filtration, recrystallization, and column chromatography, depending on the nature of the substituents. On the 2-amino group of the thiazole cycle to sulfonamide using the sulfonamidation reaction mentioned above. This efficient synthesis methodology has high yields and low First, the synthesis of the 2-amino-4-aryl-1,3-thiazoles consists of the modified Hanztch synthesis microwave-assisted. All these reactions used DMAP (N-dimethyl aminopyridine) as a catalyzer. The sulfonamidation processes used a sulfonylaryl chloride, a sulfonant reagent. Benzenesulfonamides synthesis consisted of the amino group of the 2-aminothiazole transforming into a sulfonamide through sulfonamidation. The present work describes the synthesis, isolation, and spectroscopical elucidation of 21 benzenesulfonamides derived from 2-amino-4-arylthiazoles.

Ctivo download partial